1. DHEA Dehydroepiandrosterone
Dehydroepiandrosterone (DHEA), Prasterone (INN) is most profuse steroid hormone found in humans. Based on the specific Ellen hormone levels, the hormone can act like an estrogen or an androgen in a similar way. DHEA is the originator for the male sex hormone as well as female sex hormone. It is formed in males to 100% in the inner layer (zona reticularis) of the adrenal cortex. In females, it is formed only about 70% and the other 30% is formed in the ovaries. In the biosynthesis of DHEA produced from Cholesterol through the intermediate hydroxy- pregnenolone and pregnenolone. Then, the reaction is carried out to 4-androstenedione which is in chemical balance of testosterone. Later, may be produced from testosterone 17ß-estradiol. From 4-androstenedione, is also possible the synthesis of estrone, which in turn is in equilibrium with 17ß-estradiol. The amount of DHEA produced by the body is based on the age and gender, also dependent on the DHEA concentration in the blood of a diurnal rhythm. The adrenal glands secrete in the first years of life, only small amounts of DHEA, larger quantities are first noticed in the age of 6-7 years. The secretion of DHEA is highest at the age of 25 years and after that the production of DHEA reduces back all the time.
2. DHEA and Glandular
DHEA – An abbreviation for Dehydroepiandrosterone is a steroid hormone produced from the adrenal gland. Hormones are actually substances that are developed glands or in other tissues and cells. The peptide hormone like insulin is formed by specific cells of the pancreas lowers blood sugar levels and contains chains of amino acids (peptides) or amino acid derivatives. Steroid hormones is the another group of hormone which is derived from cholesterol which include DHEA, sex hormones (androgens, estrogens), aldosterone (regulates renal function) and cortisone. DHEA and steroid hormones may, due to their lipophilic character (lipid solubility) easily pass the cell membranes and attach to the interior of the cells to a receptor protein. Sun also informs you that steroid hormones can have such a diverse effect. The hormone-receptor complex enters the nucleus and triggers the transcription (reading of genes) in such a way so that certain proteins (enzymes) can be developed.
3. TDHEA and Cancer
Amid 1972 and 1997, over four thousand publications have been published globally to DHEA, to 1991; many studies have shown its positive effect against different types of cancer, atherosclerosis, and weight loss and increased life span in animals. From 1994 was mainly researched the effect in humans and hitherto shown comparable results.
4. DHEA and Alzheimer disease
In U.S. and other countries, DHEA is already marketed significantly and sometimes referred to as a miracle cure. It is slipping out of the mostly very positive publications that DHEA enhanced the gifts Simmung, enhanced sexual activity and willingness to work against stress hormone, muscle condition to keep, strengthen the immune system and decrease cancer and heart disease risk. DHEA is found to be effective even against AIDS, osteoporosis and Alzheimer. DHEA is also prone to be closely related with it to prevent brain neurons from age-related degenerative process like Alzheimer’s. While such degenerative processes generally take place when the DHEA levels are lowest but the concentration of DHEA in brain is much higher than in blood. Dr. E. Roberts, a specialist in this field, has found that small amounts of DHEA are enough to increase the number of neurons, increase their number of contacts with other their classification in cell cultures Anzuregen. It has been discovered that DHEA has improved its long term memory in trained mice. May be, it can play the same role in human brain.
5. DHEA and Tumore
Dr. A. Schwartz of Temple University, U.S. has discovered that premiums retained of DHEA in cell cultures from the toxicity of carcinogenic factors. Generally, the cell cultures react drastically with DNA mutations, changes in cell appearance and high mortality rate. The administration of DHEA has greatly reduced these effects. In mice, treated with carcinogenic agents were those who didn’t get any additional DHEA breast cancer. In other studies, a drastic decrease in the tumor rate up to 80% was seen. [Schwartz 1981, 1984] The DHEA-known researchers stated Egelsen W. “Whenever DHEA was tested in a model environment for the development of cancer and Tumorinduzierung, DHEA had preventive effects.”
6.DHEA and Female Hormones
DHEA is the primary substance of the sex hormones and is transformed into androgens (male hormones) and estrogens (female hormones). The hormone has also affected the production of insulin-like growth factor-like growth factor 1 (IGF 1). IGF 1 is a “translator”, which helps the body to recover.
7. Positive Effects of DHEA
It has been found in many studies that DHEA strengthens the muscle and bone and leads to young skin. The hormone also improves neurological function and immune function. There are also indications that DHEA is effective in heart disease, obesity, cancer and autoimmune diseases such lupus, MS, rheumatoid arthritis. The hormone also helps in fighting against osteoporosis. A study done in California (SSCYen) has reported that DHEA intake 82% of women and67% of men felt improvement in general health. The other positive effects of DHEA included better sleep, more elasticity, better balance and easy in dealing with stressful situations.
8. DHEA and Sex Hormones
Many studies have revealed that DHEA, the enzyme glucose-6-phosphate dehydrogenase (G6PDH) prevents an enzyme that breaks down glucose. In the Pentose phosphate pathway of glucose include ribulose-5-phosphate (for the nucleotide synthesis) and 3-P-glyceraldehyde is converted, which is re-injected into the glycolysis. This subsequently leads to the formation of BTS which is later converted into AcetylCoA Others the originator of fatty acids and the fats. The Pentosephosphatzyklus plays, particularly in the liver, adipose tissue, adrenal gland, thyroid gland and the erythrocyte (red blood cells) a role, but not in the muscles. In most tissues, this pathway is related with, for example, the fatty acid synthesis. In this way, DHEA prevents fat synthesis.
DHEA production in human body is nearly 30mg of 20 years to less than 6 mg daily at the age of 80 years. As per Dr. W. Regelson, Medical College Virginia, DHEA is one of the finest biochemical markers for chronological age. For a few people, DHEA reduces during life by 95%, the biggest reduction among the main biochemical substances, this is doubtful. In animal studies, DHEA increased the lives of rodents by 50%. Not only the animals lived longer, they looked younger. The gray-haired animals could easily control the smooth black-DHEA-treated animals can be distinguished.
10.DHEA and Heart
The levels of DHEAS correlate directly with mortality (death) in humans. Twelve years in a continuous study of 240 men aged 50-79 years, researches has found that a DHEAS level is inverted related to mortality, heart attack or whether other factors have resulted in death. 1mg/Liter-Anstieg in DHEAS concentrations led to a 48% decrease in mortality from heart attack. Those having higher blood levels of DHEAS lived longer and were less likely to heart disease. The study led to the conclusion that DHEAS should be used as a diagnostic standard.
11.DHEA and LIBIDO
The Food and Drug Administration in U.S. approved a substitute DHEA could be used women with Nebennierenschwäche increase well-being and libido: A German placebo-controlled study of 24 women demonstrated that 50 mg per day DHEA increased libido and sexual Zufriedenheitsignifikant (New England Journal of Medicine).
12. Dhea Literatur
. Araghiniknam J, Chung S, Nelson-White dehydroepiandrosterone (DHEA) in older humans. Life Sci 1996; 59:147-57.
. Morales AJ, Haubrich RH, Hwang JY dehydroepiandrosterone (DHEA) on circulating sex steroids, Endocrinol (Oxf) 1998; 49:421-32.
. Brown GA, Vukovich MD, Sharp RL. Effect of oral DHEA J Appl Physiol 1999; 87:2274-83.
. Morales AJ, Nolan JJ, Nelson JC, Yen SSC. Effects of replacement dose of DHEA J Clin Endocrinol Metab 1994; 78:1360.
. McNeil C. Potential drug DHEA hits snags on way to clinic. J Natl Cancer Inst 1997; 89:681-3.
. Jones JA, Nguyen A, Strab M, et al. Use of DHEA Urology 1997; 50:784-8.
. Coleman DL, Schweizer RW and Leiter EH.dehydroepiandrosterone (DHEA) Diabetes 33: 26-32, 1984.
. Kahn, Carol. Beyond the Double Helix: DNA and the Quest for Longevity “inside” account of DHEA research.
. Coleman DL, Leiter EH and Schweizer RW. Therapeutic effects of dehydroepiandrosterone (DHEA) 31: 830-33, 1982.