1. DHEA Dehydroepiandrosterone
Dehydroepiandrosterone (DHEA), Prasterone (INN), is the most abundant steroid hormone in humans. Depending on the respective Ellen hormone levels it can behave like an estrogen or an androgen like. DHEA is the precursor for both the male sex hormones (androgens), as well as female sex Hormone. DHEA is produced in men to 100% in the inner layer (zona reticularis) of the adrenal cortex. In women, generating only about 70% the other 30% in the ovaries. In the biosynthesis of DHEA formed from cholesterol via the intermediate hydroxy-pregnenolone and pregnenolone. Thereafter, the reaction is carried out to 4-androstenedione, which is in a chemical balance of testosterone. In a next step may be formed from testosterone 17▀-estradiol. From 4-androstenedione is also possible the synthesis of estrone, which in turn is in equilibrium with 17▀-estradiol. The amount of DHEA formed by the body are dependent on the age and gender, also subject to the DHEA concentration in the blood of a diurnal rhythm. The adrenal glands produce in the first years of life, only small amounts of DHEA, larger quantities are first detected in the age of six to seven years. The production of DHEA reaches its peak around the age of 25 years and then goes back all the time.
2. DHEA and glandular
DHEA is an abbreviation for dehydroepiandrosterone, is a steroid hormone from the adrenal gland. Hormones are substances that are formed in glands or in other tissues and cells
There Peptide hormone such as: insulin, which is produced by certain cells of the pancreas and lowers blood sugar levels. They consist of chains of amino acids (peptides) or amino acid derivatives. Another group are the steroid hormones, which are derived from cholesterol. These include not only DHEA and sex hormones (androgens, estrogens) and hormones such as aldosterone (regulates the renal function) and cortisone. DHEA and steroid hormones Steroid hormones may, because of their lipophilic character (lipid solubility) easily get through the cell membranes and bind to the interior of the cells to a receptor protein. Sun also tells yo that steroid hormones can have such a varied effect. The hormone-receptor complex enters the nucleus and stimulates the transcription (reading of genes), so that specific proteins (enzymes) can be formed.
3. DHEA and cancer
Between 1972 and 1997, more than 4,000 publications have been published worldwide to DHEA, to 1991, many studies have demonstrated the positive effect against various types of cancer, atherosclerosis, weight reduction and extended life span in animals. From 1994 was mainly investigated the effect in humans and so far yielded comparable results.
4. DHEA and Alzheimer disease
In the United States and other countries already DHEA is marketed extensively and sometimes referred to as a miracle cure. It is slipping out of the mostly very positive PUBLICATIONS that DHEA improved the gifts Simmung, increase sexual activity and readiness to counteract stress hormones, muscle condition to maintain, strengthen the immune system, and reduce cancer and heart disease risk. Even against AIDS, osteoporosis and Alzheimer DHEA to be effective. DHEA is also likely to be closely associated with it to keep brain neurons from age-related degenerative processes such as Alzheimer's. Not only that such degenerative processes most often occur when the DHEA levels are lowest but the concentration of DHEA in the brain is much higher than in blood. Dr E. Roberts is a specialist in this field of research. He found that small amounts of DHEA are sufficient to increase the number of nerve cells, increasing their number of contacts with others and their differentiation in cell cultures anzuregen.DHEA has improved its long-term memory were also found in trained mice. DHEA may play a similar role in the human brain.
5. DHEA and Tumore
Dr. A. Schwartz of Temple University, USA found that premiums retained of DHEA in cell cultures from the toxicity of carcinogenic Carcinogenic factors). Typically, cell cultures react significantly with DNA mutations, changes in cell appearance and a high mortality rate. When DHEA doses, these effects were all significantly reduced. In mice treated with carcinogenic agents were those who did not receive any additional DHEA breast cancer. In other studies, a reduction of the tumor rate up to 80% was observed. [Schwartz 1981, 1984] The DHEA-known researchers noted egelsen W.: "Whenever DHEA was tested in a model environment for the development of cancer and Tumorinduzierung, DHEA had preventive effects."
6. DHEA and female hormones
DHEA is the main substance of the sex hormones and is converted into androgens (male hormones)) and estrogens (female hormones. DHEA also affected the production of insulin-like growth factor-like growth factor 1 (IGF 1). IGF 1 is a "translator", which allows the body to recover, for example), the (HGH (see below) can.
7. Positive effects of DHEA
Many studies have shown that DHEA the muscle and bone and promotes youthful skin can be yours. Likewise, it improves neurological function and immune function. There are also indications that DHEA in heart disease, obesity, cancer and autoimmune diseases (lupus, MS, rheumatoid arthritis) and helps protect against osteoporosis. A study reported from California (SSCYen) that after 2 weeks DHEA intake 82% of women and 67% of men felt an increase in general health. Also improved sleep, greater elasticity and improved balance and dealing with stressful situations was one of the positive effects,DHEA and DHEAS are obviously diverse in their metabolic effects. Here are some of them:
8. DHEA and sex hormones
Several researchers found that DHEA, the enzyme glucose-6-phosphate dehydrogenase (G6PDH) inhibits an enzyme that breaks down glucose. In the so-called Pentose phosphate pathway of glucose include ribulose-5-phosphate (for the nucleotide synthesis) and 3-P-glyceraldehyde is converted, which is re-injected into the glycolysis. Thus, BTS is then formed, which is then converted into AcetylCoA Others the precursor of fatty acids and the fats. The Pentosephosphatzyklus plays, especially in the liver, adipose tissue, adrenal gland, thyroid gland and the erythrocyte (red blood cells) play a role, but not in the muscles. In most tissues, this pathway is associated with, for example, the fatty acid synthesis.
Thus DHEA inhibits fat synthesis.
9. DHEA production
The production of DHEA in the body comes from approximately 30mg of 20 years to less than 6 mg per day at the age of 80 years. According to Dr. W. Regelson, Medical College Virginia, DHEA is one of the best biochemical marker for chronological age. For some people, DHEA decreases during life by 95%, the biggest decline among the key biochemical substances, which is unknown. In animal studies, DHEA prolonged the lives of rodents by 50%. The animals were living not only longer, looked younger. The gray-haired animals could easily control the smooth black-DHEA-treated animals can be distinguished.
10. DHEA and Heart
HEAS levels correlate directly with mortality (dying) in humans.12 years in an ongoing study of 240 men aged 50 to 79 years, researchers found that DHEAS level is inversely related to mortality, heart attack or whether other factors have resulted in death. 1mg/Liter-Anstieg in DHEAS concentrations corresponded to a 48% reduction in mortality from heart attack. Those with higher blood levels of DHEAS lived longer and had a lower risk of heart disease. These results lead to the conclusion, DHEAS use as a diagnostic standard.
11. DHEA and LIBIDO
The food in the United States approved a substitute DHEA could be used in women with Nebennierenschwńche improve well-being and libido: A German placebo-controlled study of 24 women showed that 50 mg / day DHEA increased libido and sexual Zufriedenheitsignifikant. (New England Journal of Medicine)
12. Dhea Literatur
. Araghiniknam J, Chung S, Nelson-White dehydroepiandrosterone (DHEA) in older humans. Life Sci 1996;59:147-57.
. Morales AJ, Haubrich RH, Hwang JY dehydroepiandrosterone (DHEA) on circulating sex steroids, Endocrinol (Oxf) 1998;49:421-32.
. Brown GA, Vukovich MD, Sharp RL. Effect of oral DHEA J Appl Physiol 1999;87:2274-83.
. Morales AJ, Nolan JJ, Nelson JC, Yen SSC. Effects of replacement dose of DHEA J Clin Endocrinol Metab 1994;78:1360.
. McNeil C. Potential drug DHEA hits snags on way to clinic. J Natl Cancer Inst 1997;89:681-3.
. Jones JA, Nguyen A, Strab M, et al. Use of DHEA Urology 1997;50:784-8.
. Coleman DL, Schweizer RW and Leiter EH.dehydroepiandrosterone (DHEA) Diabetes 33: 26-32, 1984.
. Kahn, Carol. Beyond the Double Helix: DNA and the Quest for Longevity "inside" account of DHEA research.
. Coleman DL, Leiter EH and Schweizer RW. Therapeutic effects of dehydroepiandrosterone (DHEA) 31: 830-33, 1982.
13. DHEA Dehydroepiandrosterone info
DHEA Dehydroepiandrosterone info:
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